Affiliation entity
BIM Biochemistry of Microbial Interactions
Thème interdisciplinaire de recherche
Extremophile microbiology, Molecular mechanisms of microbial survival under extreme conditions
Microbiology (archaea and bacteria), Molecular and cellular adaptations to extreme environments, Bioremediation, Biomineralization, Extremophiles, Astrobiology/Exobiology


adrienne.kish [at]
01 40 79 31 53

43 rue Buffon

24 allée des crapauds
75005 Paris

Responsibilities inside unit

Scientific coordinator of the MCAM Bacteriology service

Appointed member of the MCAM Research Unit Council

Responsibilities outside unit

Coordinator Units ES2 (Microbiodiversity) of the Master 1 (ES program MNHN/Sorbonne University)

Elected member of the European Astrobiology Network Association executive council

Elected member of the French Society of Exobiology adminstrative council

Online communications coordinator for MES Master (LinkedIn)

Reviewer for the journals Scientific Reports, Frontiers in Microbiology

Guest Editor, Frontiers in Microbiology Research Topic "Astrobiology At The Interface: Interactions Between Biospheres, Geospheres, Hydrospheres And Atmospheres Under Planetary Conditions"

Member of Editorial Team, Frontiers in Microbiology (Archaea), Frontiers in Astronomy and Space Sciences (Astrobiology)

Member of the grant review panel for the CNRS INSU, program INTERRVIE, action TelluS





New Article - Hot off the presses! How can microorganisms live inside a salt crystal? Doctoral candidate Charly Favreau and our fantastic team of collaborators present key new methods for isolating proteins directly & specifically from inside halite brine inclusions (microscopic drop of brine water inside NaCl salt crystals), and reveal for the first time the changes in protein expression allowing the halophilic archaeon Halobacterium salinarum to survive the early stage after evaporation within salt crystals:

Charly Favreau


New Project Funding - ExocubeHALO (Preservation of Cell Surface Biosignatures of HALOphilic Microorganisms Exposed to Space Radiation on Exocube) Franco-German collaboration between our group and that of Andreas Elsaesser (Freie Universität Berlin) to study the effects of space solar radiation on the cell envelope (S-layer) of haloarchaea has been funded by the ANR-PRCI (ANR-21-CE49-0017-01).

New Arrival - Lucas Bourmancé - We are thrilled to welcome Lucas as a doctoral researcher on the ExocubeHALO project!

New Collaboration - We have partnered with the supercritical fluids team at ICMCB ( (Samuel Marre, Anaïs Cario) to use their microfluidic systems for pre-flight testing of haloarchaea in preparation for their integration into the Exocube spaceflight experiment. Funding provided by CNES.

Research Activities

      Beyond the boundaries of the ‘ideal’ conditions for microbial life exists a diverse group of microorganisms (mostly prokaryotic bacteria and archaea) that thrive in ‘extreme’ conditions that present serious physical and chemical challenges for the survival of living organisms (pH, temperature, hydrostatic pressure, high concentrations of salts/metals, etc). These ‘extremophiles’ possess adaptations that protect them from the cellular damages induced by the surrounding environment. We use an interdisciplinary approach to characterize the molecular mechanisms enabling the survival of such microorganisms, and identify adaptations enabling survival under a variety of stress conditions. Fundamentally, understanding these mechanisms at the cellular and molecular levels increases our understanding of global biodiversity and geo(bio)chemical cycles, provides resistant biomolecules for structural studies, and even contributes to medical research in areas like DNA damage and repair (cancer). It also helps us trace the origins of life on Earth and determine the possibility for life on other planets.

     We are currently focusing on the roles of cell surface wall components called S-layers as adaptations against abiotic stresses in the environment (metals, salts, extremes in temperatures/pH, etc). S-layers are self-assembling proteinaceous structures present as well-ordered arrays on the surface of bacterial and archaeal cells as part of the cell envelope, forming their interaction interface with the external milieu. The direct contact of the S-layer with the surrounding environment provides a context for understanding mineral / microorganism interactions. S-layer proteins form an ordered structure that can serve as a site of nucleation for bio- or organo-mineralization. Preservation of S-layers during fossilization and diagenesis provides a potential biosignature for microbial life in the fossil record. The study of S-layers has implications for the origins and evolution of life on Earth, and the potential for life on other planets such as Mars.

Adrienne Kish, Kjell Ove Storvik

“The earth never tires,

The earth is rude, silent, incomprehensible at first,

Nature is rude and incomprehensible at first

Be not discouraged, keep on, there are divine things well envelop’d,

I swear to you there are divine things more beautiful than words can tell.”

            -Walt Whitman “Song of the open road”

Supervision of Early Career Researchers:

Postdoctoral Researchers

2020-2022 - Anaïs MASSÉ (ATER)

Doctoral Students

2022-2025 - Lucas BOURMANCÉ
2019-2022 - Charly FAVREAU

Diploma Students

2017-2019 - Manon VANDERVENNET (EPHE)

Research Interns (Undergraduate and Masters Students)

2022 - 2023 - ELISA RAVARO (ERASMUS+ Master thesis student researcher)
2022 - Gaëlle MARMASSE (L3), Elisa RICHARD (Reseach technician, 2nd year student), Nour BEN HAMIDA (M1 summer intern)
2021 - Louise GILLET DE CHALONGE (L3)
2019 - Charly FAVREAU (M2), Rayan ABOUD (M1)
2018 - Prithviraj DESALE (M2), Charly FAVREAU (M1), Fairouz GZARA (M1), Rey MOUROT (L3)
2017 - Archjana CHAMDRAMOHAN (M2), Rey MOUROT (L2)
2016 - Meriem DORGHAM (M2), Lea BOUTEILLE (M1), Mathilde BOUREAU (M1)
2014 - Laura BELOT (L3)

Additional Research Interests

  • Origins and evolution of microbial life
  • Astrobiology/Exobiology

<a rel="me" href="">Mastodon</a>

Selection of Articles Prior to 2012

  • Glamoclija M, Fogel M, Steele A, Kish A. (2012) Microbial Nitrogen and Sulfur Cycles at the Gypsum Dunes of White Sands National Monument, New Mexico. Geomicrobiology Journal. 29:8, 733-51.

  • Kish A, Griffin P, Rogers K, Fogel M, Hemley R, Steele A. (2012) High-Pressure Tolerance in Halobacterium salinarum NRC-1 and Other Non-Piezophilic Prokaryotes. Extremophiles. 16(2):355-61.

  • Kish A, Kirkali G, Robinson C, Rosenblatt R, Jaruga P, Dizdaroglu M, and DiRuggiero J. (2009) Salt Shield: Intracellular Salts Provide Cellular Protection against Ionizing Radiation in the Halophilic Archaeon, Halobacterium salinarum str. NRC-1. Environ Microbiol. May;11(5):1066-78.

  • Whitehead K* & Kish A*, Pan M, Kaur A, Reiss DJ, King N, Hohmann L, DiRuggiero J, Baliga NS. (2006) An integrated systems approach for understanding cellular responses to gamma radiation. Mol.Syst.Biol. 2:47. (*these authors contributed equally to this work)

  • Kottemann M, Kish A, Iloanusi C, Bjork S, DiRuggiero J. (2005) Physiological Responses of the Halophilic Archaeon Halobacterium sp. str. NRC1 to Desiccation and Gamma Irradiation. Extremophiles Jun,9(3):219-27.

Collective Activities

  • Participation in the annual “Festival of Science”
  • Member of the following professional organizations : Société Française d’Exobiologie, Société Française de Biochimie et Biologie Moléculaire, European Astrobiology Network Association, American Society for Microbiology, American Association for the Advancement of Science, Mars Society of Canada, American Geophysical Union, European Association of Geochemistry


kish_cv_2020_en.pdf Format (Pdf) - 104.36 KB



  • Favreau Charly, Tribondeau Alicia, Marugan Marie, Guyot François, Alpha-Bazin Beatrice, Marie Arul, Puppo Remy, Dufour Thierry, Huguet Arnaud, Zirah Séverine & Kish Adrienne, 2023Molecular acclimation of Halobacterium salinarum to halite brine inclusions. Frontiers in Microbiology vol. 13, , p. 1075274
  • Simonin Pierre, Lombard Carine, Huguet Arnaud & Kish Adrienne, 2020Improved Isolation of SlaA and SlaB S-layer proteins in Sulfolobus acidocaldarius. Extremophiles vol. 24, n° 4, p. 673-680
  • Chandramohan Archjana, Duprat Elodie, Remusat Laurent, Zirah Severine, Lombard Carine & Kish Adrienne, January 2019Novel Mechanism for Surface Layer Shedding and Regenerating in Bacteria Exposed to Metal-Contaminated Conditions. Frontiers in Microbiology vol. 9, , p. 3210
  • Miot J., Bernard S., Bourreau M., Guyot F. & Kish A., December 2017Experimental maturation of Archaea encrusted by Fe-phosphates. Scientific Reports vol. 7, n° 1, p. 16984
  • Kish Adrienne, Miot Jennyfer, Lombard Carine, Guigner Jean-Michel, Bernard Sylvain, Zirah Séverine & Guyot François, May 2016Preservation of Archaeal Surface Layer Structure During Mineralization. Scientific Reports vol. 6, n° 1, p. 26152
  • Kish A., Gaillard J. C., Armengaud J. & Elie C., April 2016Post-translational methylations of the archaeal Mre11:Rad50 complex throughout the DNA damage response. Molecular microbiology vol. 100, n° 2, p. 362-78
    1365-2958 (Electronic) 0950-382X (Linking)
  • Kish A., 2015« Electrophoresis » in Encyclopedia of Astrobiology.. Encyclopedia of Astrobiology , , dir. Springer-Verlag GmbH p. 718-719 DOI: 10.1007/978-3-642-11274-4